Product short description
Price:
354 EUR
Size:
100ug
Catalog no.:
GEN438255
Product detailed description
Concentration
N/A
Form/Appearance
N/A
Purification method
N/A
Gene name synonims
N/A
Gene name
NKX2-1
Clone
8G7G3/1
Category
Antibodies
Clonality
Monoclonal
Immunoglobulin isotype
IgG1, kappa
Also known as
TTF-1/ NKX2.1
Host organism
Mouse (Mus musculus)
Subcategory
Mnoclonal antibodies
Other gene names
NKX2-1; NKX2-1; BCH; BHC; NK-2; TEBP; TTF1; NKX2A; T/EBP; TITF1; TTF-1; NKX2.1; NKX2A; TITF1; TTF1; TTF-1; T/EBP
Tested applications:
ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
Storage and shipping
Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
Species reactivity
Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus). Shows a broad species reactivity.; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Other names
homeobox protein Nkx-2.1 isoform 1; Homeobox protein Nkx-2.1; homeobox protein Nkx-2.1; NK-2 homolog A; thyroid nuclear factor 1; thyroid transcription factor 1; homeobox protein NK-2 homolog A; thyroid-specific enhancer-binding protein; NK2 homeobox 1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1; Thyroid-specific enhancer-binding protein; T/EBP
Specificity and cross-reactivity
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.