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- MBS Monoclonals
- DOG-1/ ANO1
Product short description
Price:
354 EUR
Size:
100ug
Catalog no.:
GEN438426
Product detailed description
Gene name synonims
N/A
Purification method
N/A
Concentration
N/A
Form/Appearance
N/A
Also known as
DOG-1
Clone
SPM580
Gene name
TMEM16A
Clonality
Monoclonal
Category
Antibodies
Immunoglobulin isotype
IgG1, kappa
Host organism
Mouse (Mus musculus)
Subcategory
Mnoclonal antibodies
Other gene names
ANO1; ANO1; DOG1; TAOS2; ORAOV2; TMEM16A; DOG1; ORAOV2; TAOS2; TMEM16A
Tested applications:
ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
Properties
Canine or Canis Lupus is mostly Beagle used for drug research. MBS Monoclonals produces ELISA test kits and polyclonal antibodies.
Storage and shipping
Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
Species reactivity
Human (Homo sapiens).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Other names
anoctamin-1; Anoctamin-1; anoctamin-1; Ca2+-activated Cl- channel; oral cancer overexpressed 2; tumor-amplified and overexpressed sequence 2; discovered on gastrointestinal stromal tumors protein 1; transmembrane protein 16A (eight membrane-spanning domains); anoctamin 1, calcium activated chloride channel; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2
Specificity and cross-reactivity
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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