Product short description
Product detailed description
Gene name synonims
Other gene names
Also known as
Mouse (Mus musculus)
Human (Homo sapiens)
Affinity Purified by Protein G affinity chromatography.
Chain P, Single Chain Fv Of C219 Heavy Chain V101l Mutant In Complex With Synthetic Epitope Peptide; N/A
Supplied as a liquid in PBS, pH 7.4. No stabilizing proteins added. No preservative added. Glycerol free. Also available with BSA. See C0026-11Q.
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Storage and shipping
Store the antibody at +4 degrees Celsius for short term storage.. Aliquot to avoid repeated freezing and thawing. For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Specificity and cross-reactivity
Recognizes human c-erbB2. Inhibits the binding of EGF and NDF to their direct receptors. Inhibits tumorigenic growth. Demonstrates modest effect on c-erbB-2 internalization. Induces the tyrosine kinase activity of the c-erbB-2. Accelerates dissociation of EGF/NDF from their cellular binding sites. Inhibits mitogenic effect of EGF/NDF. Inhibits dimerization of c-erbB Receptors.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
Sodium azide NaN3 is often used to prevent antibody degradation in 0,02% W/V concentrations. MBS Monoclonals supplies azide free antibodies on request.Recently MBS Monoclonals made this c-erbB2 (HER-2, neu Receptor) (BSA ) available without azide. It will stick less and is more suitable for ELISA or in vivo studies. However you need to store the @VV@ frozen and ship on dry ice.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.