c-erbB2 (HER-2, neu Receptor)

652 EUR

500ul

GEN600260

N/A

N/A

N/A

N/A

IgG1

3F32

c-erbB2

Antibodies

Monoclonal

Mnoclonal antibodies

Mouse (Mus musculus)

Human (Homo sapiens)

Immunoprecipitation (IP)

Affinity Purified by Protein G affinity chromatography.

Chain P, Single Chain Fv Of C219 Heavy Chain V101l Mutant In Complex With Synthetic Epitope Peptide; N/A

Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See C0026-11MX

Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Store the antibody at +4 degrees Celsius for short term storage.. Aliquot to avoid repeated freezing and thawing. For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Recognizes human c-erbB2. Reacts with the intact cells, shows no effect on internalization of c-erbB-2, strongly stimulates (>10-fold) the tyrosine kinase activity and promotes (~40%) the tumorigenic growth in CD1/nude mice of N87 human gastric carcinoma cell line overexpressing c-erbB-2. Does not react with mouse and rat.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.