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- CD89 (Fc alpha R, FCAR, Immunoglobulin alpha Fc Receptor, IgA Fc Receptor)
Product short description
Price:
647 EUR
Size:
200ug
Catalog no.:
GEN601371
Product detailed description
Additional isotype
IgA
Gene name
N/A
Gene name synonims
N/A
Other gene names
N/A
Concentration
N/A
Other names
N/A
Immunoglobulin isotype
IgG1
Also known as
CD89
Clone
3H1742
Clonality
Monoclonal
Category
Antibodies
Purification method
Purified IgG.
Host organism
Mouse (Mus musculus)
Subcategory
Mnoclonal antibodies
Source organism
Human (Homo sapiens)
Storage and shipping
Store the antibody at -20 degrees Celsius.
Form/Appearance
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Tested applications:
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Species reactivity
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Properties
Immunoglobulin A (IgA, also referred to as sIgA) is an antibody that plays a critical role in immune function in the mucous membranes. More IgA is produced in mucosal linings than all other types of antibody combined. Examples are EMA, ACA ELISA test kits and for diagnostic detection the IgA of Anti-Beta-2 Glycoprotein 1; β2-Glycoprotein 1 Antibodies; Beta 2GP1 Ab, Beta-2 Glycoprotein 1 Antibodies IgG, IgM, and IgAs.
Specificity and cross-reactivity
Recognizes the human CD89 cell surface antigen, a 50-75kD cell surface glycoprotein that is also known as the IgA receptor (Fc alpha R).CD89 is expressed by peripheral blood monocytes and neutrophils. 3H1742 blocks binding of IgA to the Fc alpha R and also inhibits neutrophil phagocytosis of IgA complexes. The preservative free format of this antibody is recommended for functional studies.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
Description
The CD89 (Fc alpha R, FCAR, Immunoglobulin alpha Fc Receptor, IgA Fc Receptor) is a α- or alpha protein sometimes glycoprotein present in blood.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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