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- c-erbB2 (HER-2, neu Receptor)
Product short description
Price:
652 EUR
Size:
500ul
Catalog no.:
GEN601751
Product detailed description
Concentration
N/A
Gene name
N/A
Gene name synonims
N/A
Other gene names
N/A
Clone
3F36
Immunoglobulin isotype
IgG1,k
Also known as
c-erbB2
Category
Antibodies
Clonality
Monoclonal
Subcategory
Mnoclonal antibodies
Host organism
Mouse (Mus musculus)
Source organism
Human (Homo sapiens)
Tested applications:
Immunoprecipitation (IP)
Purification method
Affinity Purified by Protein G affinity chromatography.
Other names
Chain P, Single Chain Fv Of C219 Heavy Chain V101l Mutant In Complex With Synthetic Epitope Peptide; N/A
Form/Appearance
Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide. Also available without BSA and azide. See C0026-11QX.
Species reactivity
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Storage and shipping
Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze atStore the antibody at -20 degrees Celsius. or colder. Aliquots are stable for at least 12 months atStore the antibody at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Specificity and cross-reactivity
Recognizes human c-erbB2. Inhibits the binding of EGF and NDF to their direct receptors. Inhibits tumorigenic growth. Demonstrates modest effect on c-erbB-2 internalization. Induces the tyrosine kinase activity of the c-erbB-2. Accelerates Dissociation of EGF/NDF from their Cellular Binding Sites. Inhibits Mitogenic Effect of EGF/NDF. Inhibits Dimerization of c-erbB Receptors. Epitope: Involved in the formation of heterodimers.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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