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- MBS Monoclonals
- c-erbB2 (HER-2, neu Receptor) (BSA & Azide Free)
Product short description
Price:
724 EUR
Size:
100ul
Catalog no.:
GEN602771
Product detailed description
Concentration
N/A
Gene name
N/A
Gene name synonims
N/A
Other gene names
N/A
Immunoglobulin isotype
IgG1
Clone
3F30
Also known as
c-erbB2
Category
Antibodies
Clonality
Monoclonal
Subcategory
Mnoclonal antibodies
Host organism
Mouse (Mus musculus)
Source organism
Human (Homo sapiens)
Tested applications:
Immunohistochemistry (IHC), Immunofluorescence (IF)
Purification method
Affinity Purified by Protein G affinity chromatography.
Form/Appearance
Supplied as a liquid in PBS, pH 7.4. Also available with BSA and azide. See C0026-11K
Other names
Chain P, Single Chain Fv Of C219 Heavy Chain V101l Mutant In Complex With Synthetic Epitope Peptide; N/A
Species reactivity
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Storage and shipping
Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Specificity and cross-reactivity
Recognizes human c-erbB2. Reacts with the intact cells, shows moderate effect on c-erbB-2 internalization, slightly increases (~2-fold) the tyrosine kinase activity, and inhibits (~90%) the tumorigenic growth in CD1/nude mice of N87 human gastric carcinoma cell line overexpressing c-erbB-2. Does not react with mouse and rat.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
Description
Sodium azide NaN3 is often used to prevent antibody degradation in 0,02% W/V concentrations. MBS Monoclonals supplies azide free antibodies on request.Recently MBS Monoclonals made this c-erbB2 (HER-2, neu Receptor) (BSA ) available without azide. It will stick less and is more suitable for ELISA or in vivo studies. However you need to store the @VV@ frozen and ship on dry ice.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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