Integrin, alpha1, beta1 (CD49a, VLA alpha1, Laminin Receptor, Collagen Receptor)

674 EUR

100ug

GEN604033

N/A

N/A

N/A

N/A

N/A

2Q1015

IgG2a,k

Antibodies

Monoclonal

Mnoclonal antibodies

Mouse (Mus musculus)

Integrin, alpha1, beta1

Rat (Rattus norvegicus)

Affinity Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.

Collagen Types in bones and muscles can be hydrolyzed and used in human grafts. ( Type II )

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze the antibody should be stored at -20 degrees Celsius.. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Directed against rat integrin a1b1 (VLA-1). Specificity was confirmed by ability to immunoprecipitate alpha1 (Mr~200kD) and beta1 (Mr~120kD) from 125I-surface labeled PC12 cells as well as reciprocal depletion of VLA-1 antigen from cell lysate with antiserum against the cytoplasmic domain of a1 integrin subunit. Does not inhibit VLA-1 mediated adhesion to matrix proteins.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.