Tumor Necrosis Factor alpha, Low Endotoxin (TNFa, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, Cachectin, TNF, TNFA, TNFSF2)

707 EUR

500ug

GEN605888

N/A

IgG1

tumor

10F541

Antibodies

Monoclonal

tnfa; N/A; N/A; N/A

tnfa; N/A; N/A; N/A

tnfa; N/A; N/A; N/A

Mouse (Mus musculus)

Mnoclonal antibodies

Rat (Rattus norvegicus)

Tumor Necrosis Factor alpha, Low Endotoxin

Affinity Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.4. No preservatives added.

ELISA (EL/EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

tumor necrosis factor alpha; N/A; tumor necrosis factor alpha; N/A; N/A

Mouse (Mus musculus), Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Recognizes mouse TNF, alpha. Species Crossreactivity: rat. ; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

Store the antibody at +4 degrees Celsius for short term storage.. Aliquot to avoid repeated freezing and thawing. For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

The Tumor Necrosis Factor alpha, Endotoxin (TNFa, TNF-alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, Cachectin, TNF, TNFA, TNFSF2) is a α- or alpha protein sometimes glycoprotein present in blood.Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.