Stat3, phosphorylated (Ser727) (Signal Transducer and Activator of Transcription 3, Acute-phase Response Factor, APRF)

625 EUR

100ul

GEN609444

N/A

Stat3

IgG2b

3H422

Purified

Antibodies

Monoclonal

Mouse (Mus musculus)

Mnoclonal antibodies

Mouse (Mus musculus)

STAT3; STAT3; APRF; HIES; APRF

STAT3; STAT3; APRF; HIES; APRF

STAT3; STAT3; APRF; HIES; APRF

Supplied as a liquid in 10mM HEPES, pH 7.5, 150 mM sodium chloride, 100ug/ml BSA,

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Human (Homo sapiens), Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

signal transducer and activator of transcription 3 isoform 1; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3; DNA-binding protein APRF; acute-phase response factor; signal transducer and activator of transcription 3 (acute-phase response factor); Acute-phase response factor

Store the antibody at +4 degrees Celsius for short term storage.. Long-term storage should be done after aliquoting the antibody and freezing the aliqotes at -20 degrees Celsius. Under these conditions the aliquots will be stable for at least one year if kept at -20 °C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Recognizes human Stat3 when phosphorylated at Serine 727. Does not cross-react with the corresponding phosphorylated serines of other Stat proteins. Does not react with nonphosphorylated Stat3 or with Stat3 phosphorylated at other sites. Species Crossreactivity: mouse.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. Transcription factors, unites and elongations can be RNA and DNA nucleic acids, base pairs of nucleotides . Converting from DNA to RNA is made by enzymatic reactions. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. Transcriptions are key functions in signal transduction pathways. Signaling ligand binding transcription factors play an important role in transduction cascades.