MOUSE Anti-CLOSTRIDIUM TETANI TETANUS TOXIN Antibody

531 EUR

200ug

GEN216320

N/A

IgG1

TetH6

anticorps

Antibodies

Monoclonal

Mus musculus

Mnoclonal antibodies

Mouse (Mus musculus)

IgG concentration 1.0mg/ml

CLOSTRIDIUM TETANI TETANUS TOXIN

Purified (Purified IgG - liquid)

tetX; tetX; N/A; Tetanus toxin chain L

tetX; tetX; N/A; Tetanus toxin chain L

tetX; tetX; N/A; Tetanus toxin chain L

ELISA (EIA), Functional Assay (FA), Western Blot (WB)

tetanus toxin tetX; Tetanus toxin; tetanus toxin tetX; N/A; Tentoxylysin

If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Bacterial; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.

CLOSTRIDIUM TETANI TETANUS TOXIN This item recognises the tetanus toxin, a neurotoxin produced by the vegetative spore of Clostridium tetani. The toxin causes tetanus, a disease that is characterised by prolonged contraction of skeletal muscle. World-wide, approximately 1 million cases of tetanus occurs annually, resulting in approximately 300,000 to 500,000 deaths, mostly in developing countries. The tetanus toxin has a molecular weight of approximately 150kDa and consists of a heavy chain (B-chain, 100kDa) and a light chain (A-chain, 50kDa) that are connected by a disulfide bond. The toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits the release of the neurotransmitters GABA and glycine by synaptobrevin-2. This results in overactivity in the muscle. The binding of the toxin to neurons is irreversible. _x000D__x000D_This item has toxin neutralising activity. Removal of sodium azide is recommended prior to use in functional assays -; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.