MOUSE Anti-RAT CD252:Low Endotoxin Antibody

608 EUR

500ug

GEN219443

N/A

N/A

IgG1

CD252

CD252

ATM-2

anticorps

Monoclonal

Antibodies

Mouse (Mus musculus)

Mnoclonal antibodies

IgG concentration 1.0mg/ml

Mus musculus,Rattus norvegicus

Low Endotoxin (Purified IgG - liquid)

Tnfsf4; Tnfsf4; Ox40l; Ox40l; Txgp1; OX40L

Flow Cytometry (FACS), Functional Assay (FA)

If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

tumor necrosis factor ligand superfamily member 4; Tumor necrosis factor ligand superfamily member 4; tumor necrosis factor ligand superfamily member 4; OX40 ligand; tumor necrosis factor (ligand) superfamily, member 4; OX40 ligand

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Store the antibody should be stored at -20 degrees Celsius. only. Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

CD252 This item specifically recognises rat CD252, otherwise known as OX40L or CD134L, a 22kDa type II transmembrane glycoprotein and member of the TNF superfamily, expressed by antigen-presenting cells including activated dendritic cells and B cells, and also by vascular endothelium. _x000D__x000D_The interaction of CD252 with its receptor OX40/CD134, acts as a co-stimulator of T cell activation, proliferation and both Th1 and Th2 cytokine production, and is also important in activated B cell proliferation and secretion of immunoglobulins (Igs). CD252/OX40 interaction has been implicated in HTLV-1 associated diseases including myelopathy and adult T cell leukaemia, and also with the autoimmune diseases rheumatoid arthritis and inflammatory bowel disease. _x000D__x000D_Clone ATM-2 has been shown to block the co-stimulatory activity of CD252 on rat T cell proliferation.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.