MOUSE Anti-RAT CD80:Low Endotoxin Antibody

608 EUR

500ug

GEN219739

N/A

3H5

N/A

CD80

CD80

IgG1

anticorps

Monoclonal

Antibodies

N/A; Cd80; N/A; N/A

Mouse (Mus musculus)

Mnoclonal antibodies

CD80; CD80; N/A; N/A; N/A

IgG concentration 1.0mg/ml

Mus musculus,Rattus norvegicus

Low Endotoxin (Purified IgG - liquid)

Immunohistology - Frozen (IHC), Flow Cytometry (FACS), Functional Assay (FA), Immunoprecipitation (IP)

If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Store the antibody should be stored at -20 degrees Celsius. only. Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

CD80 This item specifically recognises rat CD80, otherwise known as B7-1, a type I transmembrane glycoprotein and member of the Ig superfamily, which acts as a ligand for both CD28 and CD152 (CTLA-4), and is primarily expressed on antigen presenting cells (APCs) including dendritic cells. _x000D_CD80 is a B cell activation antigen, which functions in the CD28-CD80/CD86 co-stimulatory pathway vital for T cell activation and proliferation. In contrast, the interaction of CD80 with CD152 has an inhibitory effect on T cell responses. _x000D_Clone 3H5 has been shown to block the co-stimulatory activity of rat CD80.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.