RAT ANTI MOUSE TIM-1 Antibody

481 EUR

100ug

GEN224461

N/A

N/A

TIM-1

TIM-1

IgG2a

RMT1-10

anticorps

Antibodies

Monoclonal

Mnoclonal antibodies

Rat (Rattus norvegicus)

Mus musculus,Rattus norvegicus

Purified (Purified IgG - liquid)

IgG concentration 1 miligram per 1 mililiter

Flow Cytometry (FACS), Immunofluorescence (IF), ELISA (EIA)

Havcr1; Havcr1; Tim1; KIM-1; TIM-1; Timd1; AI503787; Kim1; Tim1; Timd1; HAVcr-1; KIM-1; TIMD-1

If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.This is against a protein of mus musculus directed antibody.

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term. the antibody should be stored undiluted. Storage in frost-free freezers is not recommended. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.

hepatitis A virus cellular receptor 1 homolog isoform b; Hepatitis A virus cellular receptor 1 homolog; hepatitis A virus cellular receptor 1 homolog; TIMD-1; HAVcr-1; kidney injury molecule 1; t cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; t cell immunoglobulin and mucin domain-containing protein 1; hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM-1; T cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; T cell membrane protein 1; TIM-1

TIM-1 Clone MBS239187-10 specifically recognises mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b). _x000D__x000D_Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity. _x000D__x000D_Polymorphic forms of Tim-1 are associated with increased susceptibility to asthma, eczema and Rheumatoid arthritis. _x000D__x000D_Clone MBS239187-10 has been shown to promote Th2 responses, and inhibit antigen-specific T cell proliferation, in contrast to the agonistic function of many Tim-1 antibodies.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.