Mouse Monoclonal (IgG1) to Rat Growth Hormone Receptor / GHR Antibody

597 EUR

50ug

GEN245213

GHR

N/A

N/A

IgG1

anticorps

Antibodies

Monoclonal

Protein A Purified

Mnoclonal antibodies

Mouse (Mus musculus)

1 miligram per 1 mililiter

Growth Hormone Receptor / GHR

Mus musculus,Rattus norvegicus

PBS, pH 7.2, 0.09% sodium azide

GHR; GHR; GHBP; GH receptor; GH-binding protein; GHBP

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)

If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

For long term storage, keep the antibody at -20 degrees Celsius. Short term storage of the antibody can be done at +4 degrees Celsius. Cycles of freezing/defrosting can damage the peptide chains of the antibodies thus reducing the activity.

Human (Homo sapiens), Rabbit (Oryctolagus cuniculus), Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

growth hormone receptor isoform 1; Growth hormone receptor; growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein; growth hormone receptor; Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Recognizes rat growth hormone receptor. The antibody has been shown to partially block binding of GH in rabbit and rat and has been used as a growth hormone agonist. Has been validated for detection of GHR in formalin-fixed/paraffin-embedded human tissues.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Hormone releasing factors and releasing hormones are  signaling molecules produced by glands in multicellular organisms. The glands that secrete Luteinizing hormones LHRG and LH, FSH comprise the endocrine signaling system. The term growth hormone releasing hormone GHRH is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or intracrine signaling) or nearby cells (paracrine signaling). Human recombinant LHRG and GHRH are produced in E. coli or in yeast cells.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.