LAP2 (Lamina Associated Polypeptide 2, Thymopoietin, TMPO) Antibody

735 EUR

200ul

GEN602293

N/A

N/A

N/A

IgG

N/A

LAP2

4i386

Hamster

anticorps

Monoclonal

Antibodies

IgG fraction.

Mnoclonal antibodies

Rat (Rattus norvegicus)

Leucine aminopeptidase 2; N/A

Supplied as a liquid in PBS with 0.05% sodium azide.

Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Detects Lamin Associated Polypeptide (LAP) 2 from various rat tissues but does not crossreact with LAP 1A, 1B & 1C. Recognizes a single 53kD protein representing LAP 2 in rat liver nuclear envelope fractions.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze the antibody should be stored at -20 degrees Celsius.. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. Prior to use, briefly centrifuge the original vial after thawing and before lid. If further dilution(s) are needed, they can be done with the appropriate assay buffer.

Thymopoietin I and II are proteins involved in the induction of CD90 in the thymus. The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. The human TMPO gene maps to chromosome band 12q22 and consists of eight exons. TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the nuclear membrane. TMPO beta is a human homolog of the murine protein LAP2. LAP2 plays a role in the regulation of nuclear architecture by binding lamin B1 and chromosomes. This interaction is regulated by phosphorylation during mitosis. Given the nuclear localization of the three TMPO isoforms, it is unlikely that these proteins play any role in CD90 induction.