Mouse Anti-Human Tollip-UNLB

470 EUR

100ug

GEN670158

N/A

N/A

SB40a

Tollip

Antibodies

Monoclonal

Mouse IgG2a

Mus musculus

Mouse (Mus musculus)

Mnoclonal antibodies

Purified (UNLB) Antibody

ELISA; Flow Cytometry; Western Blot

TOLLIP; TOLLIP; FLJ33531; IL-1RAcPIP; N/A

TOLLIP; TOLLIP; FLJ33531; IL-1RAcPIP; N/A

TOLLIP; TOLLIP; FLJ33531; IL-1RAcPIP; N/A

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

toll-interacting protein; TOLLIP protein; toll-interacting protein; adapter protein; OTTHUMP00000164471; OTTHUMP00000232257; OTTHUMP00000232258; OTTHUMP00000232259; OTTHUMP00000232262; toll interacting protein; N/A

The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. Reagents are stable for the period shown on the label if stored as directed.

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

MBS Monoclonals supplies antibodies that are for research of human proteins.Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Human Tollip; Does not react to TLR2, TLR4, TLR6, TLR7, TLR8 and TLR10 recombinant proteins Tollip, Toll-interacting protein, is a 30 kDa adaptor protein that is a component of the signaling pathway of IL-1 and Toll-like receptors. Tollip forms a complex with IRAK (IL-1 receptor associated kinase) and inhibits IL-1-induced signaling by blocking IRAK phosphorylation. The co-recruitment of MyD88 triggers IRAK autophosphorylation, which in turn leads to the rapid dissociation of IRAK and Tollip. Tollip is also an important signaling component of the TLR2 and TLR4 pathways by playing an inhibitory role in TLRmediated cell activation. Tollip also associates with Tom1 (target of Myb1) forming a complex which regulates endosomal trafficking of ubiquitinated proteins. 1-6; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.