Mouse Anti-Human CD40-UNLB

299 EUR

100ug

GEN670183

N/A

N/A

N/A

N/A

N/A

CD40

IgG1

HB14

CD40; N/A

Antibodies

Monoclonal

Mus musculus

Mnoclonal antibodies

Mouse (Mus musculus)

Purified (UNLB) Antibody

Flow Cytometry, B cell assays

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

The purified (UNLB) antibody is supplied as 0.1 mg purified immunoglobulin in 0.5 mL of phosphate buffered saline containing 0.1% PBS/NaN3. Store the antibody ats should be kept in the range of 1-7 degrees Celsius..

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

MBS Monoclonals supplies antibodies that are for research of human proteins.Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Human CD40 CD40, a member of the TNFR-SF, is a 45-48 kDa type I integral membrane glycoprotein whose ligand is CD154. It is expressed on all mature B lymphocytes, but is absent from plasma cells. It is also present on some epithelial and endothelial cells. CD154 binding to CD40 on B cells is important for T cell/B cell interactions and is required for secondary immune responses. Evidence for a role of CD40-CD154 interaction in negative selection and peripheral tolerance has been suggested. CD40 monoclonal antibodies have been reported to stimulate B cell proliferation when costimulated with anti-u, CD20 monoclonal antibodies or phorbol esters.1-3; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.