Mouse Anti-Human CD49e-UNLB

437 EUR

100ug

GEN670203

N/A

N/A

N/A

N/A

N/A

N/A

CD49e

IgG2b

SAM-1

Antibodies

Monoclonal

Mus musculus

Mnoclonal antibodies

Mouse (Mus musculus)

Purified (UNLB) Antibody

Flow Cytometry, Immunohistochemistry (Frozen sections), Function blocking

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of PBS/NaN3. Store the antibody ats should be kept in the range of 1-7 degrees Celsius..

Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

MBS Monoclonals supplies antibodies that are for research of human proteins.Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Human CD49e CD49e is the integrin alpha5 chain, a 135/25 kDa heterodimer, that associates oncovalently with CD29, the integrin beta1 subunit, to form the alpha5beta1 very late antigen-5 (VLA-5) complex, a very well established fibronectin receptor that is expressed on many cell types, including thymocytes, T cells, monocytes and platelets. Expression of the VLA-5 heterodimer is increased on activated and memory T cells. It is also found on very early B cells and on activated B lymphocytes. CD49e/CD2-mediated binding to fibronectin provides a costimulatory signal to T cells. It also enhances FcgammaR- and complement receptor-mediated phagocytosis, and is involved in monocyte migration into extracellular tissues.1-6; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.