Rat anti-Human Caspase-2-UNLB

348 EUR

100ug

GEN670331

IgM

N/A

N/A

SB123a1

Caspase-2

Antibodies

Monoclonal

Western Blot

Rattus norvegicus

Mnoclonal antibodies

Rat (Rattus norvegicus)

Purified (UNLB) Antibody

Casp2; Casp2; ICH-1; Nedd2; Caspase-2; Ich1; Nedd-2; Nedd2; CASP-2; NEDD-2

Casp2; Casp2; ICH-1; Nedd2; Caspase-2; Ich1; Nedd-2; Nedd2; CASP-2; NEDD-2

Casp2; Casp2; ICH-1; Nedd2; Caspase-2; Ich1; Nedd-2; Nedd2; CASP-2; NEDD-2

MBS Monoclonals supplies antibodies that are for research of human proteins.

Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

caspase-2; Caspase-2; caspase-2; CASP-2; NEDD-2; protease ICH-1; neural precursor cell expressed developmentally down-regulated protein 2; caspase 2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

The purified (UNLB) antibody is supplied as 0.1mg purified immunoglobulin in 0.1 mL of 100 mM borate buffered saline, pH 8.0; Store the antibody ats should be kept in the range of 1-7 degrees Celsius.. Reagents are stable for the period shown on the label if stored as directed.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Reacts with human Caspase 21 The Caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intraand extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis. Caspase 2 (ICH-1/Nedd2) is an initiator caspase that is prevalent in both the cytosol and nucleus in many cell types3. During embryonic development it is expressed at relatively high levels in the central nervous system, liver, kidney and lungs and is prevalent in numerous tissues in adults4,5. Studies have shown that Caspase 2 becomes activated in response to several lethal stimuli including DNA damage, ER stress and death receptor stimulation and further evidence has suggested a role in reactive oxygen species-induced cell death2,6-9. The SB123a monoclonal antibody detects bands at ~40 and ~48 kD, corresponding to cleaved and uncleaved forms of Caspase 2, respectively.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.