Rat Anti-Mouse CD105-UNLB

365 EUR

500ug

GEN673616

N/A

N/A

N/A

N/A

N/A

N/A

MJ7/18

Monoclonal

CD105/Endoglin

Rat IgG2a kappa

Secondary Antibodies

Mnoclonal antibodies

Rat (Rattus norvegicus)

Purified (UNLB) Antibody

Mus musculus,Rattus norvegicus

Flow Cytometry; Immunocytochemistry; Immunohistochemistry (Frozen Sections); Western Blot

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. Protect conjugated forms from light. Reagents are stable for the period shown on the label if stored as directed.

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Mouse endoglin, Mr 90kDa CD105/endoglin is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages and lymphoid and myeloid leukemic cells.2 Both mouse and human CD105 exhibit >70% sequence homology in their cytoplasmic domains with type III transforming growth factor beta (TGF beta) receptor.3 CD105 has been shown to be one of several receptors for the various isoforms of TGF beta, which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells and control of the immune response.4; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.