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- Cyclin D1
Product short description
Price:
354 EUR
Size:
100ug
Catalog no.:
GEN438067
Product detailed description
Concentration
N/A
Form/Appearance
N/A
Purification method
N/A
Gene name synonims
N/A
Gene name
CCND1
Clone
SPM587
Also known as
Cyclin D1
Clonality
Monoclonal
Category
Antibodies
Immunoglobulin isotype
IgG2a, kappa
Host organism
Mouse (Mus musculus)
Subcategory
Mnoclonal antibodies
Other gene names
CCND1; CCND1; BCL1; PRAD1; U21B31; D11S287E; BCL1; PRAD1; BCL-1
Tested applications:
ELISA, Biological Function Blockade, Flow Cytometry, Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistology
Storage and shipping
Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
Other names
G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; BCL-1 oncogene; PRAD1 oncogene; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; cyclin D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene
Species reactivity
Human (Homo sapiens), Monkey, Mouse (Mus musculus), Rat (Rattus norvegicus).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Specificity and cross-reactivity
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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