Antitrypsin Activated Protein C (APC-AAT complexes, alpha1 Proteinase Inhibitor, alpha1 PI, native and denatured)

724 EUR

100ul

GEN601232

7

N/A

IgG1,k

Antibodies

Monoclonal

ELISA (EL/EIA)

Mouse (Mus musculus)

Mnoclonal antibodies

Human (Homo sapiens)

Antitrypsin Activated Protein C

SERPINA3; SERPINA3; ACT; AACT; GIG24; GIG25; AACT; ACT

SERPINA3; SERPINA3; ACT; AACT; GIG24; GIG25; AACT; ACT

SERPINA3; SERPINA3; ACT; AACT; GIG24; GIG25; AACT; ACT

Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.

Affinity Purified by Protein A/G affinity chromatography from culture supernatant.

Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

alpha-1-antichymotrypsin; Alpha-1-antichymotrypsin; alpha-1-antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Cell growth-inhibiting gene 24/25 protein; Serpin A3

Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze the antibody should be stored at -20 degrees Celsius.. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Has specificity for a conformation-dependent neoepitope that is expressed in activated protein C upon complex-formation with a1-antitrypsin. No reaction is seen to non-complexed a1-antitrypsin and only very little cross reaction to protein C zymogen. Note that specificity is calcium dependent.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.