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- MBS Monoclonals
- HAMSTER ANTI HIGH MOBILITY GROUP PROTEIN B1 Antibody
Product short description
Price:
525 EUR
Size:
100ug
Catalog no.:
GEN224509
Product detailed description
Immunoglobulin isotype
IgG
Purification method
N/A
Host organism
Hamster
Clone
HMG1-5H6
French translation
anticorps
Clonality
Monoclonal
Category
Antibodies
Subcategory
Mnoclonal antibodies
Concentration
IgG concentration 1.0mg/ml
Also known as
HIGH MOBILITY GROUP PROTEIN B1
Form/Appearance
Purified (Purified IgG - liquid)
Other gene names
HMGB1; HMGB1; HMG1; HMG3; SBP-1; HMG1; HMG-1
Gene name synonims
HMGB1; HMGB1; HMG1; HMG3; SBP-1; HMG1; HMG-1
Gene name
HMGB1; HMGB1; HMG1; HMG3; SBP-1; HMG1; HMG-1
Tested applications:
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blot (WB)
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Species reactivity
Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Properties
If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Armenian of Syrian hamster monoclonal IgGs are useful antibodies for double staining your IHC samples. Using mabs or monoclonal antibodies has a lot of advantages for Flow cytometry.
Other names
high mobility group protein B1; High mobility group protein B1; high mobility group protein B1; HMG-1; Amphoterin; high-mobility group box 1; high mobility group protein 1; Sulfoglucuronyl carbohydrate binding protein; high-mobility group (nonhistone chromosomal) protein 1; high mobility group box 1; High mobility group protein 1
Storage and shipping
Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.
Specificity and cross-reactivity
HIGH MOBILITY GROUP PROTEIN B1 This item specifically recognises High mobility group protein B1 (HMGB1), a ubiquitously expressed nuclear DNA binding protein, and one of a newly emerging group of alarmins, which acts as a stabilizer of nucleosome formation, and facilitates transcription factor binding, by bending DNA. _x000D__x000D_HMGB1 is one of the signature danger signals of endogenous cellular injury, and is released outside the cell by necrotic and inflammatory cells to act as a chemoattractant for immature dendritic cells (DCs), promoting their maturation. DCs can also secrete HMGB1, promoting proliferation and Th1 polarization of interacting T cells. Cellular injury resulting in necrosis, leads to passive HMGB1 release, and microbes or pro-inflammatory cytokines may later stimulate active release from APCs. _x000D__x000D_HMGB1 is emerging as a prime specific marker and regulator of necrotic cell death, possibly through the PI3KC3-MEK-ERK pathway. It interacts directly with the autophagy protein Beclin-1, and binds to receptors, such as RAGE on endothelial cells, and Toll-like receptors on macrophages. Studies identifying microtubule-associated protein 1 light chain 3 (LC3) lipidation and redistribution, coupled with the accumulation of autophagosomes and autolysosomes, have shown an important role for HMGB1 release in sustaining autophagy. Studies have also shown that HMGB1 released after chemotherapy treatment is a critical regulator of autophagy, and a potential drug target for therapeutic interventions in leukemia. _x000D__x000D_HMGB1 is increasingly recognised as an important protein in medical research. It is angiogenic and promotes cardiac stem cell growth and differentiation, it may act as an adjuvant or assist in tissue repair, and is also a prototypical damage-associated molecular pattern molecule (DAMP) which co-precipitates with CD24 and is associated with the hallmarks of cancer. Accelerated levels of HMGB1 are seen in several cancers and correlates with metastatic act; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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