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- MBS Monoclonals
- c-erbB2 (HER-2, neu Receptor) Antibody
Product short description
Price:
652 EUR
Size:
500ul
Catalog no.:
GEN603080
Product detailed description
Gene name
N/A
Gene name synonims
N/A
Other gene names
N/A
Concentration
N/A
Immunoglobulin isotype
IgG1
Clone
3F30
Also known as
c-erbB2
French translation
anticorps
Clonality
Monoclonal
Category
Antibodies
Host organism
Mouse (Mus musculus)
Subcategory
Mnoclonal antibodies
Source organism
Human (Homo sapiens)
Purification method
Affinity Purified by Protein G affinity chromatography.
Tested applications:
Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
Other names
Chain P, Single Chain Fv Of C219 Heavy Chain V101l Mutant In Complex With Synthetic Epitope Peptide; N/A
Form/Appearance
Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See C0026-11KX
Properties
If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Species reactivity
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
Storage and shipping
Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. Prior to use, briefly centrifuge the original vial after thawing and before lid. If further dilution(s) are needed, they can be done with the appropriate assay buffer.
Specificity and cross-reactivity
Reacts with the intact cells,1,2 shows moderate effect on c-erbB-2 internalization,1 slightly increases (~2-fold) the tyrosine kinase activity,1 and inhibits (~90%) the tumorigenic growth in CD1/nude mice of N87 human gastric carcinoma cell line overexpressing c-erbB-2.1,2,3 Species Crossreactivity: human. Does not react with mouse and rat.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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